研究業績（論文・総説・学会発表）

実臨床における細胞診検体を用いた肺がんコンパクトパネル™の有用性について
Clinical Usefulness of the Lung Cancer Compact Panel™ Using Cytological Specimens for the Diagnosis of Lung Cancer Patients

東山聖彦, 小林周平, 野尻 崇, 宇田裕史, 井上正義, 山内 周, 佐藤慶治.
Higashiyama M, Kobayashi S, Nojiri T, Uda H, Inoue M, Yamauchi A, Sato Y.

肺癌. 2023;63(4):285-291
The Japan Journal of Lung Cancer. 2023;63(4):285-291 
2023

https://www.jstage.jst.go.jp/article/haigan/63/4/63_285/_article/-char/ja/

EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC

Morikawa K, Kinoshita K, Matsuzawa S, Kida H, Handa H, Inoue T, Nakamura S, Sato Y, Mineshita M.

Diagnostics. 2023;13:2327 
2023

https://www.mdpi.com/2075-4418/13/14/2327

q-mer analysis: a generalized method for analyzing RNA-Seq data

Shoji T, Sato Y.

Journal of Bioinformatics and Systems Biology. 2023;6(1):60-72
2023

https://www.fortunejournals.com/articles/qmer-analysis-a-generalized-method-for-analyzing-rnaseq-data.html

Analytical Performance of a Highly Sensitive System to Detect Gene Variants Using Next-Generation Sequencing for Lung Cancer Companion Diagnostics

Kato K, Okami J, Nakamura H, Honma K, Sato Y, Nakamura S, Kukita Y, Nakatsuka S, Higashiyama M.

Diagnostics (Basel). 2023 Apr 19;13(8):1476. 
2023

https://www.mdpi.com/2075-4418/13/8/1476

Impact of the lipase inhibitor orlistat on the human gut microbiota

Uehira Y, Ueno H, Miyamoto J, Kimura I, Ishizawa Y, Iijima H, Muroga S, Fujita T, Sakai S, Samukawa Y, Tanaka Y, Murayama S, Sakoda H, Nakazato M.

Obes Res Clin Pract. 2023 Sep-Oct;17(5):411-420. 
2023

https://www.sciencedirect.com/science/article/pii/S1871403X23000704

Exome-wide benchmark of difficult-to-sequence regions using short-read next-generation DNA sequencing

Hijikata A, Suyama M, Kikugawa S, Matoba R, Naruto T, Enomoto Y, Kurosawa K, Harada N, Yanagi K, Kaname T, Miyako K, Takazawa M, Sasai H, Hosokawa J, Itoga S, Yamaguchi T, Kosho T, Matsubara K, Kuroki Y, Fukami M, Adachi K, Nanba E, Tsuchida N, Uchiyama Y, Matsumoto N, Nishimura K, Ohara O.

Nucleic Acids Res. 2023 Nov 28:gkad1140.
2023

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad1140/7453260

細胞診検体を用いた肺がんコンパクトパネルによる 次世代シーケンシングの有用性
Usefulness of the High-sensitivity Lung Cancer Compact Panel™ with Cytological Specimens

南大輔, 瀧川奈義夫, 多田陽郎, 中島康博, 宮原信明, 水守康之, 植田充宏, 佐藤慶治, 森川 慶, 金廣有彦.
Minami D, Takigawa N, Tada A, Nakajima Y, Miyahara N, Mizumori Y, Ueda M, Sato Y, Morikawa K, Kanehiro A.

肺癌. 2022;62(7):989-995 
2022

https://www.jstage.jst.go.jp/article/haigan/62/7/62_989/_article/-char/ja/

Fragment size and dynamics of EGFR‑mutated tumor‑derived DNA provide prognostic information regarding EGFR‑TKI efficacy in patients with EGFR‑mutated NSCLC

Kunimasa K, Nishino K, Sato Y, Mori M, Ihara S, Suzuki H, Nagatomo I, Kumagai T, Morishima T, Imamura F.

Sci Rep. 2022 Aug 8;12(1):13544
2022

https://www.nature.com/articles/s41598-022-17848-y

Use of a highly sensitive lung cancer compact panel to detect KRAS G12D in the wash fluid from a lung tumor: A case report

Minami D, Takigawa N, Nakajima Y, Miyahara N, Mizumori Y, Ueda M, Nakamura S, Suzuki F, Sato Y, Morikawa K, Kanehiro A.

Thoracic Cancer. 2022;13(11):1735-1738
2022

https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.14439

Use of a highly sensitive lung cancer compact panel to detect KRAS G12D in the wash fluid from a lung tumor: A case report

Minami D, Takigawa N, Nakajima Y, Miyahara N, Mizumori Y, Ueda M, Nakamura S, Suzuki F, Sato Y, Morikawa K, Kanehiro A.

Thoracic Cancer. 2022;13(11):1735-1738
2022

https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.14439

A long-term responding epidermal growth factor

Miyazaki K, Sato Y, Satoh H, Hizawa N.

Contemp Oncol (Pozn). 2022;26(1):88-89
2022

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052343/

RET fusion mutation detected by re-biopsy 7 years after initial cytotoxic chemotherapy: A case report

Morikawa K, Handa H, Ueno J, Tsuruoka H, Inoue T, Shimada N, Koike J, Nakamura S, Sato Y, Mineshita M.

Frontiers in Oncology. 2022;12:1019932
2022

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1019932/full

A Prospective Validation Study of Lung Cancer Gene Panel Testing Using Cytological Specimens

Morikawa K, Kida H, Handa H, Inoue T, Saji H, Koike J, Nakamura S, Sato Y, Ueda Y, Suzuki F, Matoba R, Mineshita M.

Cancers (Basel). 2022 Aug 3;14(15):3784
2022

https://www.mdpi.com/2072-6694/14/15/3784

Clinical utility of liquid biopsy-based companion diagnostics in the non-small-cell lung cancer treatment

Sato Y.

Exploration of Targeted Anti-tumor Therapy. 2022;3:630-642
2022

https://www.explorationpub.com/Journals/etat/Article/1002104

Significance of Polar Charged Amino Acids in Compound Mutations in EGFR-mutated Patients Treated With First-line Afatinib

Satoh H, Sasatani Y, Miyazaki K, Sato Y, Hizawa N.

in vivo. 2022;36:1829-1833
2022

https://iv.iiarjournals.org/content/36/4/1829.abstract

Prognostic significance associated with the number of compound mutations in epidermal growth factor receptor–mutated non–small cell lung cancer

Satoh H, Sasatani Y, Miyazaki K, Sato Y, Hizawa N.

Polish Archives of Internal Medicine 2022;132(4):16240
2022

https://www.mp.pl/paim/issue/article/16240/

Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry.

Nakano M, Yui H, Kikugawa S, Tokida R, Sakai N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T, Kato H, Takahashi J, Nakamura Y.

Ther Clin Risk Manag. 2021;17:1065-1073
2021

https://doi.org/10.2147/TCRM.S330530

EML4-ALK fusion variant.3 and co-occurrent PIK3CA E542K mutation exhibiting primary resistance to three generations of ALK inhibitors.

Kunimasa K, Hirotsu Y, Kukita Y, Ueda Y, Sato Y, Kimura M, Otsuka T, Hamamoto Y, Tamiya M, Inoue T, Kawamura T, Nishino K, Amemiya K, Goto T, Mochizuki H, Honma K, Omata M, Kumagai T.

Cancer Genet. 2021 May 28;256-257:131-135.
2021

https://www.sciencedirect.com/science/article/abs/pii/S2210776221001162

STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.

Fujisawa F, Kunimasa K, Kano-Fujiwara R, Sato Y, Kusama H, Nishio M, Matsui S, Yoshinami T, Kittaka N, Nakamura H, Nagata S, Honma K, Yagi T, Nakayama T, Tamaki Y, Imamura F.

Breast Cancer. 2021 May;28(3):765-771.
2021

https://link.springer.com/article/10.1007/s12282-020-01200-1

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors.

Nakatake Y, Ko SBH, Sharov AA, Wakabayashi S, Murakami M, Sakota M, Chikazawa N, Ookura C, Sato S, Ito N, Ishikawa-Hirayama M, Mak SS, Jakt LM, Ueno T, Hiratsuka K, Matsushita M, Goparaju SK, Akiyama T, Ishiguro KI, Oda M, Gouda N, Umezawa A, Akutsu H, Nishimura K, Matoba R, Ohara O, Ko MSH.

Cell Rep. 2020 May 19;31(7):107655.
2020

https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(20)30608-2

Observation of p.R4810K, a Polymorphism of the Mysterin Gene, the Susceptibility Gene for Moyamoya Disease, in Two Female Japanese Diabetic Patients with Familial Partial Lipodystrophy 1.

Iwanishi M, Azuma C, Tezuka Y, Yamamoto Y, Ito-Kobayashi J, Washiyama M, Kusakabe T, Kikugawa S.

Intern Med. 2020;59(20):2529-2537.
2020

https://www.jstage.jst.go.jp/article/internalmedicine/59/20/59_4042-19/_article

Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis.

Yokoyama-Kokuryo W, Yamazaki H, Takeuchi T, Amano K, Kikuchi J, Kondo T, Nakamura S, Sakai R, Hirano F, Nanki T, Koike R, Harigai M.

Arthritis Res Ther. 2020 Mar 12;22(1):46.
2020

https://doi.org/10.1186/s13075-020-2137-y

DELIVER (JACCRO GC-08) trial: discover novel host-related immune-biomarkers for nivolumab in advanced gastric cancer.

Sunakawa Y, Inoue E, Matoba R, Kawakami H, Sato Y, Nakajima TE, Muro K, Ichikawa W. And Fujii M.

Future Oncol. 2019 Jul;15(21):2441-2447.
2019

https://doi.org/10.2217/fon-2019-0167

Detection of gene mutations in gastric cancer tissues using a commercial sequencing panel.

Ito T, Matoba R, Maekawa H, Sakurada M, Kushida T, Orita H, Wada R, Sato K.

Molecular and Clinical Oncology 11: 455-460, 2019
2019

https://www.spandidos-publications.com/mco/11/5/455/abstract

Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis.

Sato M, Yamato M, Mitani G, Takagaki T, Hamahashi K, Nakamura Y, Ishihara M, Matoba R, Kobayashi H, Okano T, Mochida J, Watanabe M.

npj Regenerative Medicine volume 4, Article number: 4 (2019)
2019

http://www.nature.com/articles/s41536-019-0069-4

Recent Advances in Liquid Biopsy in Precision Oncology Research.

Sato Y, Matoba R, Kato K.

Biol Pharm Bull. 2019;42(3):337-342
2019

https://doi.org/10.1248/bpb.b18-00804

Practical determination of LODP (limit of detection for microarray platform) for the evaluation of microarray platforms.

Adachi S, Aoki H, Ueda Y, Sudo T, Nozawa A, Koga S, Suzuki H, Shibayama S, Noda N, Fujii SI, Itoh S, Kawashima S, Suda Y, Nakae H.

Anal Biochem. 2019 Oct 15;583:113360
2019

https://www.sciencedirect.com/science/article/abs/pii/S0003269719303872?via%3Dihub

Olfactomedin-like protein OLFML1 inhibits Hippo signaling and mineralization in osteoblasts.

Murakami K, Kikugawa S, Kobayashi Y, Uehara S, Suzuki T, Kato H, Udagawa N, Nakamura Y.

Biochemical and Biophysical Research Communications, Volume 505, Issue 2, 2018, Pages 419-425
2018

https://doi.org/10.1016/j.bbrc.2018.09.112

Identification of baseline gene expression signatures predicting therapeutic effects of TNF inhibitors in rheumatoid arthritis patients.

Nakamura S, Suzuki K, Kaneko Y, Takeuchi T, Amano K

Clin Rheumatol Rel Res. 30: 300-307, 2018
2018

https://doi.org/10.1186/s13075-016-1052-8

FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells.

Yashiro M, Ohya M, Mima T, Ueda Y, Nakashima Y, Kawakami K, Ishizawa Y, Yamamoto S, Kobayashi S, Yano T, Tanaka Y, Okuda K, Sonou T, Shoshihara T, Iwashita Y, Iwashita Y, Tatsuta K, Matoba R, Negi S, Shigematsu T

Int J Nephrol Renovasc Dis. 2018:11 125-136.
2018

https://www.dovepress.com/fgf23-modulates-the-effects-of-erythropoietin-on-gene-expression-in-re-peer-reviewed-article-IJNRD

Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.

Hori H, Nakamura S, Yoshida F, Teraishi T, Sasayama D, Ota M, Hattori K, Kim Y, Higuchi T, Kunugi H.

J Psychiatr Res. 2018 Sep;104:202-210.
2018

https://www.sciencedirect.com/science/article/pii/S0022395618306101

Copy number loss in the region of ASPN gene in patients with acetabular dysplasia.

Sekimoto T, Ishii M, Emi M, Kurogi S, Funamoto T, Hamada H, Chosa E.

Bone & Joint Res 2017 (in press)
2017

https://online.boneandjoint.org.uk/doi/full/10.1302/2046-3758.67.BJR-2016-0094.R1

Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study.

Ohnishi J, Ayuzawa S, Nakamura S, Sakamoto S, Hori M, Sasaoka T, Takimoto-Ohnishi E, Tanatsugu M and Murakami K.

Human Genomics 2017 11:22.
2017

https://humgenomics.biomedcentral.com/articles/10.1186/s40246-017-0117-3

Whole-exome sequencing and digital PCR identified a novel compound heterozygous mutation in NPHP1 gene inn a case of Joubert syndrome and related disorders.

Koyama S, Sato H, Kawakami T, Emi M, Kato T.

BMC Med Genetics, 2017, 37-41
2017

https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0399-2

Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration.

Yokoyama M, Sato M, Umezawa A, Mitani G, Takagaki T, Yokoyama M, Kawake T, Okada E, Kokubo M, Ito N, Takaku Y, Murai K, Matoba R, Akutsu H, Yamato M, Okano T, Mochida J

Tissue Eng Part C Methods. 2016 Jan;22(1):59-68.
2016

http://online.liebertpub.com/doi/abs/10.1089/ten.TEC.2015.0254?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses.

Hori H, Sasayama D, Teraishi T, Yamamoto N, Nakamura S, Ota M, Hattori K, Kim Y, Higuchi T, Kunugi H.

Sci Rep. 2016 Jan 5;6:18776.
2016

http://www.nature.com/articles/srep18776

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.

Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.

Proc. National. Acad. Sci. USA: November 9, 2016.
2016

http://www.pnas.org/content/113/47/13432.long

Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study.

Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, Kameda H, Amano K, Matsubara K, Matoba R, Takeuchi T.

Arthritis Research & Therapy. 2016 Jul 19;18:159.
2016

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1052-8

Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects.

Obata Y, Maeda N,Yamada Y, Yamamoto K, Nakamura S, Yamaoka M, Tanaka Y, Masuda S, Nagao H, Fukuda S, Fujishima Y, Kita S,Nishizawa H, Funahashi T,Matsubara KI, Matsuzawa Y, Shimomura

Cardiovasc Diabetol. 2016 Nov 29;15(1):159.
2016

https://cardiab.biomedcentral.com/articles/10.1186/s12933-016-0479-1

Profiling of exercise-induced transcripts in the peripheral blood cells of Thoroughbred horses.

Tozaki T, Kikuchi M, Kakoi H, Hirota KI, Mukai K, Aida H, Nakamura S, Nagata SI

J Equine Sci. 2016;27(4):157-164.
2016

https://www.jstage.jst.go.jp/article/jes/27/4/27_1616/_article

miR-340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator.

Yamashita D, Kondo T, Ohue S, Takahashi H, Ishikawa M, Matoba R, Suehiro S, Kohno S, Harada H, Tanaka J. and Ohnishi T.

Cancer Res. 75(6) (2015) 1123-1133.
2015

https://cancerres.aacrjournals.org/content/75/6/1123.long

A set of external reference controls/probes that enable quality assurance between different microarray platforms.

Akiyama H, Ueda Y, Nobumasa H, Ooshima H, Ishizawa Y, Kitahiro K, Miyagawa I, Watanabe K, Nakamura T, Tanaka R, Yamamoto N, Nakae H, Kawase M, Gemma N, Sekiguchi Y, Fujibuchi W, Matoba R.

Anal Biochem. 2015 Mar 1;472:75-83.
2015

http://www.sciencedirect.com/science/article/pii/S0003269714005417

Chlorella ingestion suppresses resistin gene expression in peripheral blood cells of borderline diabetics.

Itakura H, Kobayashi M, Nakamura S

Clinical Nutrition ESPEN Volume 10, Issue 3, June 2015, Pages e95-e101
2015

http://www.clinicalnutritionespen.com/article/S2405-4577(15)00096-0/fulltext

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s.

Carbone M, Flores EG, Emi M, Johnson TA, Tsunoda T, Behner D, Hoffman H, Hesdorffer M, Nasu M, Napolitano A, Powers A, Minaai M, Baumann F, Bryant-Greenwood P, Lauk O, Kirschner MB, Weder W, Opitz I, Pass HI, Gaudino G, Pastorino S, Yang H.

PLoS Genet. 2015 Dec 18;11(12):e1005633.
2015

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005633

Frequent genomic rearrangements of BRCA1 associated protein-1 (BAP1) gene in Japanese malignant mesothelioma-characterization of deletions at exon level.

Emi M, Yoshikawa Y, Sato C, Sato A, Sato H, Kato T, Tsujimura T, Hasegawa S, Nakano T, Hashimoto-Tamaoki T.

J Hum Genet. 2015 Oct;60(10):647-9.
2015

https://doi.org/10.1038/jhg.2015.91

High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.

Nasu M, Emi M, Pastorino S, Tanji M, Powers A, Luk H, Baumann F, Zhang YA, Gazdar A, Kanodia S, Tiirikainen M, Flores E, Gaudino G, Becich MJ, Pass HI, Yang H, Carbone M.

J Thorac Oncol. 2015 Apr;10(4):565-76.
2015

http://www.jto.org/article/S1556-0864(15)32358-3/fulltext

High-fidelity target sequencing of individual molecules identified using barcode sequences: de novo detection and absolute quantitation of mutations in plasma cell-free DNA from cancer patients.

Kukita Y, Matoba R, Uchida J, Hamakawa T, Doki Y, Imamura F, Kato K.

DNA Res. 2015 Aug;22(4):269-77.
2015

https://academic.oup.com/dnaresearch/article-lookup/doi/10.1093/dnares/dsv010

Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.

Karasaki T, Nagayama K, Kawashima M, Hiyama N, Murayama T, Kuwano H, Nitadori JI, Anraku M, Sato M, Miyai M, Hosoi A, Matsushita H, Kikugawa S, Matoba R, Ohara O, Kakimi K, Nakajima J.

J Thorac Oncol. 2015 Dec 29. pii: S1556-0864(15)00076-3.
2015

http://www.jto.org/article/S1556-0864(15)00076-3/fulltext

Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes.

Fukuda A, Tanino M, Matoba R, Umezawa A, Akutsu H.

Sci Rep. 2015 Sep 15;5:14101.
2015

http://www.nature.com/articles/srep14101

PCSK5 mutation in a patient with the VACTERL association.

Nakamura Y, Kikugawa S, Seki S, Takahata M, Iwasaki N, Terai H, Matsubara M, Fujioka F, Inagaki H, Kobayashi T, Kimura T, Kurahashi H, Kato H.

BMC Res Notes. 2015 Jun 9;8:228.
2015

https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1166-0

Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma.

Mori T, Sumii M, Fujishima F, Ueno K, Emi M, Nagasaki M, Ishioka C, Chiba N.

Cancer Sci. 2015 Sep;106(9):1118-29.
2015

http://onlinelibrary.wiley.com/doi/10.1111/cas.12722/abstract

Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.

Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K, Gascoyne RD, Yoshino T.

Cancer Sci. 2014 May;105(5):608-15
2014

https://doi.org/10.1111/cas.12392

Increased Protein and mRNA Expression of Resistin After Dexamethasone Administration.

Sasayama D, Hori H, Nakamura S, Yamamoto N, Hattori K, Teraishi T, Ota M, Kunugi H

Horm Metab Res. 2014 Jul 10.
2014

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0034-1383651

ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1.

Sasayama D, Hori H, Yamamoto N, Nakamura S, Teraishi T, Tatsumi M, Hattori K, Ota M, Higuchi T, Kunugi H.

J Psychiatr Res. 2014 Mar;50:79-83.
2014

http://www.journalofpsychiatricresearch.com/article/S0022-3956(13)00368-3/fulltext

Large-Scale East-Asian eQTL Mapping Reveals Novel Candidate Genes for LD Mapping and the Genomic Landscape of Transcriptional Effects of Sequence Variants.

Narahara M, Higasa K, Nakamura S, Tabara Y, Kawaguchi T, Ishii M, Matsubara K, Matsuda F, Yamada R1.

PLoS One. 2014 Jun 23;9(6):e100924.
2014

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100924

Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome).

Yamaoka M, Maeda N, Nakamura S, Mori T, Inoue K, Matsuda K, Sekimoto R, Kashine S, Nakagawa Y, Tsushima Y, Fujishima Y, Komura N, Hirata A, Nishizawa H, Matsuzawa Y, Matsubara K, Funahashi T, Shimomura I

Biochem Biophys Res Commun. 2013 Apr 19;433(4):450-5.
2013

http://www.sciencedirect.com/science/article/pii/S0006291X13004014

Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells.

Li Y, Drnevich J, Akraiko T, Band M, Li D, Wang F, Matoba R, Tanaka TS.

Genomics. 2013 Nov-Dec;102(5-6):456-67.
2013

http://www.sciencedirect.com/science/article/pii/S0888754313001857

Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population.

Sasayama D, Hori H, Nakamura S, Miyata R, Teraishi T, Hattori K, Ota M, Yamamoto N, Higuchi T, Amano N, Kunugi H.

PLoS One. 2013;8(1):e54967.
2013

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054967

Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes.

Nakata S, Imagawa A, Miyata Y, Yoshikawa A, Kozawa J, Okita K, Funahashi T, Nakamura S, Matsubara K, Iwahashi H, Shimomura I

Immunol Lett. 2013 Nov-Dec;156(1-2):149-55.
2013

http://www.sciencedirect.com/science/article/pii/S0165247813001636

Segmental copy number loss in the region of Semaphorin 4D gene in patients with acetabular dysplasia.

Sekimoto T, Ishii M, Emi M, Kurogi S, Funamoto T, Hamada H, Chosa E.

J Orthop Res. 2013 Jun;31(6):957-61.
2013

http://onlinelibrary.wiley.com/doi/10.1002/jor.22310/abstract

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.

Hikichi T1, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6412-7.
2013

http://www.pnas.org/content/110/16/6412.long

Large-scale genome reorganization in Saccharomyces cerevisiae through combinatorial loss of mini-chromosomes.

Ueda Y, Ikushima S, Sugiyama M, Matoba R, Kaneko Y, Matsubara K. and Harashima S.

J Biosci Bioeng. Jun;113 (2012) 675-682.
2012

http://dx.doi.org/10.1016/j.jbiosc.2012.01.013

Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells.

Morita S, Takahashi R, Yamashita R, Toyoda A, Horii, T, Kimura M, Fujiyama A, Nakai K, Tajima S, Matoba R, Ochiya T. and Hatada I.

Int. J. Mol. Sci. 13 (2012) 8259-8272.
2012

https://dx.doi.org/10.3390%2Fijms13078259

A Pilot Investigation of Visceral Fat Adiposity and Gene Expression Profile in Peripheral Blood Cells.

Yamaoka M, Maeda N, Nakamura S, Kashine S, Nakagawa Y, Hiuge-Shimizu A, Okita K, Imagawa A, Matsuzawa Y, Matsubara K, Funahashi T, Shimomura I.

PLoS One. 2012;7(10):e47377.
2012

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047377

Frequent inactivation of BAP1 gene in epithelioid-type malignant mesothelioma.

Yoshikawa Y, Sato A, Tsujimura T, Emi M, Morinaga T, Fukuoka K, Yamada S, Murakami A, Kondo N, Matsumoto S, Okumura Y, Tanaka F, Hasegawa S, Nakano T, Hashimoto-Tamaoki T

Cancer Sci. 2012 May;103(5):868-74
2012

http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2012.02223.x/abstract

Genome-wide copy number analysis in primary breast cancer.

Ueno T, Emi M, Sato H, Ito N, Muta M, Kuroi K, Toi M

Expert Opin Ther Targets. 2012 Mar;16 Suppl 1:S31-5
2012

http://www.tandfonline.com/doi/full/10.1517/14728222.2011.636739

Identification of blood biomarkers of aging by transcript profiling of whole blood.

Nakamura S, Kawai K, Takeshita Y, Honda M, Takamura T, Kaneko S, Matoba R, Matsubara K

Biochem Biophys Res Commun. 2012 Feb 10;418(2):313-8.
2012

http://www.sciencedirect.com/science/article/pii/S0006291X12000411

Heterogeneity of colorectal cancers and extraction of discriminator gene signatures for personalized prediction of prognosis.

Miyake M, Takemasa I, Matoba R, Tanino M, Niijima S, Ikeda M, Yamamoto H, Sekimoto M, Kuhara S, Okayama T, Monden M, Matsubara K. and Mori M.

Int J Oncol. 39 (2011) 781-789.
2011

http://dx.doi.org/10.3892/ijo.2011.1092

Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.

Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K.

Mol Brain. 2011 Jun 10;4:24.
2011

https://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-4-24

Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus.

Kudo H, Emi M, Ishigaki Y, Tsunoda U, Hinokio Y, Ishii M, Sato H, Yamada T, Katagiri H, Oka Y.

Exp Diabetes Res. 2011;2011:498460.
2011

https://www.hindawi.com/journals/jdr/2011/498460/

Influence of Chlorella powder intake during swimming stress in mice.

Mizoguchi T, Arakawa Y, Kobayashi M, Fujishima M.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):121-6.
2011

http://www.sciencedirect.com/science/article/pii/S0006291X10021443

Molecular analysis of TSC2/PKD1 contiguous gene deletion syndrome.

Oyazato Y, Iijima K, Emi M, Sekine T, Kamei K, Takanashi J, Nakao H, Namai Y, Nozu K, Matsuo M

Kobe J. Med. Sci. 2011; 57: 1.
2011

http://www.med.kobe-u.ac.jp/journal/contents/57/E1.pdf

Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: a community-based study.

Kato T, Sato H, Emi M, Seino T, Arawaka S, Iseki C, Takahashi Y, Wada M, Kawanami T.

Intern Med. 2011;50(4):297-303. Epub 2011 Feb 15.
2011

https://www.jstage.jst.go.jp/article/internalmedicine/50/4/50_4_297/_article

Spread of X-chromosome inactivation into chromosome 15 is associated with Prader-Willi syndrome phenotype in a boy with a t(X;15)(p21.1;q11.2) translocation.

Sakazume S, Ohashi H, Sasaki Y, Harada N, Nakanishi K, Sato H, Emi M, Endoh K, Sohma R, Kido Y, Nagai T, Kubota T.

J Human Genet, 2011 Epub Jul 7
2011

https://link.springer.com/article/10.1007%2Fs00439-011-1051-4

Copy number variation: experimental procedures and statistical analysis.

Sato H, Emi M.

Nippon Rinsho. 2010 Aug;68(8):76-9.
2010

http://www.nippon-rinsho.co.jp/backnum/z_mokuji/6808idensi.html

Effect of exercise on gene expression profile in unfractionated peripheral blood leukocytes.

Nakamura S, Kobayashi M, Sugino T, Kajimoto O, Matoba R, Matsubara K.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):846-51.
2010

http://www.sciencedirect.com/science/article/pii/S0006291X09023468

HNF1B Alterations Associated with Congenital Anomalies of the Kidney and Urinary Tract.

Nakayama M, Nozu K, Goto Y, Kamei K, Ito S, Sato H, Emi M, Nakanishi K, Tsuchiya S, Iijima K

Pediatr Nephrol. 2010 Jun;25(6):1073-9.
2010

https://link.springer.com/article/10.1007%2Fs00467-010-1454-9

Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.

Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F, Sobue G, Matsubara K.

Biochem Biophys Res Commun. 2010 Nov 12;402(2):438-42.
2010

http://www.sciencedirect.com/science/article/pii/S0006291X10019339

The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study.

Konta T, Takasaki S, Ichikawa K, Emi M, Toriyama S, Satoh H, Ikeda A, Suzuki K, Mashima Y, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I.

J Hum Genet. 2010 Sep 16.
2010

https://doi.org/10.1038/jhg.2010.113

Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.

Yang D, Yaguchi T, Lim CR, Ishizawa Y, Nakano T, Nishizaki T.

Cancer Lett. 2010 May 28;291(2):225-9.
2010

http://www.cancerletters.info/article/S0304-3835(09)00638-7/fulltext

Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray.

Narumi S, Numakura C, Shiihara T, Seiwa C, Nozaki Y, Yamagata T, Momoi MY, Watanabe Y, Yoshino M, Matsuishi T, Nishi E, Kawame H, Akahane T, Nishimura G, Emi M, Hasegawa T

Am J Med Genet A. 2010 Jan;152A(1):133-40.
2010

http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.33177/abstract;jsessionid=5617475376D1BD9B442D3D330CCA6D88.f02t04

Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.

Yang D, Yaguchi T, Lim CR, Ishizawa Y, Nakano T, Nishizaki

T.Cancer Lett. 2010 May 28;291(2):225-9. doi: 10.1016/j.canlet.2009.10.016. Epub 2009 Nov 8.
2010

https://www.sciencedirect.com/science/article/abs/pii/S0304383509006387?via%3Dihub

Dicer is required for maintaining adult pancreas.

Morita, S, Hara, A, Kojima, I, Horii, T, Kimura, M, Kitamura, T, Ochiya, T, Nakanishi, K, Matoba, R, Matsubara, K. and Hatada, I.

PLoS One. 4 (2009) e4212.
2009

https://doi.org/10.1371/journal.pone.0004212

Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition.

Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K, Yoneda Y.

Brain Res. 1287 (2009) 136-145.
2009

https://doi.org/10.1016/j.brainres.2009.06.050

Screening of potential molecular targets for colorectal cancer therapy.

Honma K, Takemasa I, Matoba R, Yamamoto Y, Takeshita F, Mori M, Monden M, Matsubara K and Ochiya T.

Int J Gen Med. 29 (2009) 243-257.
2009

https://doi.org/10.2147/IJGM.S5158

Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women.

Ichikawa K, Konta T, Emi M, Toriyama S, Takasaki S, Ikeda A, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I

Kidney Int. 2009 Jul;76(2):183-9.
2009

https://doi.org/10.1038/ki.2009.97

Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis.

Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S

J Bone Miner Metab. 2009;27(2):213-6.
2009

https://link.springer.com/article/10.1007%2Fs00774-008-0031-9

Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells.

Tanino M, Matoba R, Nakamura S, Kameda H, Amano K, Okayama T, Nagasawa H, Suzuki K, Matsubara K, Takeuchi T.

Biochem Biophys Res Commun. 2009 Sep 18;387(2):261-5.
2009

http://www.sciencedirect.com/science/article/pii/S0006291X09013163

A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.

Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T.

FEBS J. 2008 Mar;275(6):1260-73. doi: 10.1111/j.1742-4658.2008.06287.x.
2008

http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2008.06287.x/abstract;jsessionid=2243B893C28CA8557A754877FB65B46C.f02t04

A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM.

Susa S, Daimon M, Sakabe J, Sato H, Oizumi T, Karasawa S, Wada K, Jimbu Y, Kameda W, Emi M, Muramatsu M, Kato T

Biochem Biophys Res Commun. 2008 May 9;369(3):943-7. Epub 2008 Mar 6.
2008

http://www.sciencedirect.com/science/article/pii/S0006291X08004117

Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population: the Takahata study.

Konta T, Emi M, Toriyama S, Ariumi H, Ishii M, Takasaki S, Ikeda A, Ichikawa K, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I

J Hum Genet. 2008;53(3):267-74. Epub 2008 Jan 24.
2008

https://link.springer.com/article/10.1007/s10038-008-0246-6

Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis.

Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S

J Hum Genet. 2008;53(8):694-7. Epub 2008 May 17.
2008

https://doi.org/10.1007/s10038-008-0300-4

Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity.

Koyano S, Emi M, Saito T, Makino N, Toriyama S, Ishii M, Kubota I, Kato T, Kawata S

Hepatol Res. 2008 Jul;38(7):696-703. Epub 2008 Mar 4.
2008

http://onlinelibrary.wiley.com/doi/10.1111/j.1872-034X.2008.00327.x/abstract

Establishment of Rat Embryonic Stem Cells and Making of Chimera Rats.

Ueda S, Kawamata M, Teratani T, Shimizu T, Tamai Y, Ogawa H, Hayashi K, Tsuda H, Ochiya T.

PLoS One. 2008 Jul 30;3(7):e2800.
2008

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002800

Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan.

Wada M, Daimon M, Emi M, Iijima H, Sato H, Koyano S, Tajima K, Kawanami T, Kurita K, Hunt SC, Hopkins PN, Kubota I, Kawata S, Kato T

J Atheroscler Thromb. 2008 Aug;15(4):179-84.
2008

https://www.jstage.jst.go.jp/article/jat/15/4/15_E542/_article

Genomic approaches to bone and joint diseases. A genome-wide approach for analysis of polygenic diseases.

Sato H, Emi M

Clin Calcium. 2008 Feb;18(2):176-81.
2008

https://www.ncbi.nlm.nih.gov/pubmed/18245886

Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides.

Komatsu, Y, Kojima, N, Sugino, M, Mikami, A, Nonaka, K, Fujinawa, Y, Sugimoto, T, Sato, K, Matsubara, K. and Ohtsuka, E.

Bioorg. Med. Chem. , 16, 941-949 (2008).
2008

http://www.sciencedirect.com/science/article/pii/S0968089607008565

Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.

Daimon M, Sato H, Sasaki S, Toriyama S, Emi M, Muramatsu M, Hunt SC, Hopkins PN, Karasawa S, Wada K, Jimbu Y, Kameda W, Susa S, Oizumi T, Fukao A, Kubota I, Kawata S, Kato T

Biochem Biophys Res Commun. 2008 Sep 26;374(3):576-80. Epub 2008 Jul 24.
2008

http://www.sciencedirect.com/science/article/pii/S0006291X08014137

A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.

Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T.

FEBS J. 2008 Mar;275(6):1260-73. doi: 10.1111/j.1742-4658.2008.06287.x.
2008

https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2008.06287.x

Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray.

Iwahashi H, Kitagawa E, Suzuki Y, Ueda Y, Ishizawa YH, Nobumasa H, Kuboki Y, Hosoda H, Iwahashi Y.

BMC Genomics. 2007 Apr 5;8:95.
2007

https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-8-95

Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes.

Takamura T, Honda M, Sakai Y, Ando H, Shimizu A, Ota T, Sakurai M, Misu H, Kurita S, Matsuzawa-Nagata N, Uchikata M, Nakamura S, Matoba R, Tanino M, Matsubara K, Kaneko S

Biochem Biophys Res Commun. 2007 Sep 21;361(2):379-84.
2007

http://www.sciencedirect.com/science/article/pii/S0006291X07014623

Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue.

Kojima N, Sugino M, Mikami A, Nonaka K, Fujinawa Y, Muto I, Matsubara K, Ohtsuka E, Komatsu Y.

Bioorg. Med. Chem. Lett, 16, 5118-5121 (2006).
2006

http://www.sciencedirect.com/science/article/pii/S0960894X06008031

Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling

Kawakami K, Enokida H, Tachikawa T, Gotanda T, Tsuneyoshi K, Kubo H, Nishiyama K, Takiguchi M, Nakagawa M, Seki N.

Oncol Rep. 2006, 16(3):521-31
2006

Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines

Mikata R, Yokosuka O, Fukai K, Imazeki F, Arai M, Tada M, Kurihara T, Zhang K, Kanda T, Saisho H.

Int J Cancer. 2006, vol.119, pp1616-1622
2006

Arpc1b Gene Is a Candidate Prediction Marker for Choroidal Malignant Melanomas Sensitive to Radiotherapy

Ken Kumagai, Yoshinori Nimura, Atsushi Mizota, Nobuyuki Miyahara, Mizuho Aoki, Yoshiya Furusawa, Masaki Takiguchi, Shuichi Yamamoto, and Naohiko Seki

Invest Ophthalmol Vis Sci, 2006, 47(6):2300-4
2006

Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.

Shiraishi K, Yamasaki K, Nanba D, Inoue H, Hanakawa Y, Shirakata Y, Hashimoto K, Higashiyama S.

Oncogene. 2006 Jul 24; [Epub ahead of print]
2006

PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.

Kikugawa T, Kinugasa Y, Shiraishi K, Nanba D, Nakashiro K, Tanji N, Yokoyama M, Higashiyama S.

Prostate. 2006 Jul 1;66(10):1092-9.
2006

Naked gene therapy of hepatocyte grouth factor for dextran sulfate sodium-induced colitis in mice

T.Kanbe, R.Murai, T.Mukoyama, Y.Murawaki, K.Hashiguchi, Y.Yoshida, H.Tsuchiya, A.Kurimasa, K.Harada, K.Yashima, E.Nishimuki, N.Shabana, Y.Kishimoto, H.Kojyo, K.Miura, Y.Murawaki, H.Kawasaki, G.Shiota

Biochemical and Biophysical Research Communications, 345(2006) 1517-1525
2006

Characterization of Gene Expression Profiles of Metallothionein-Null Cadmium-Resistant Cells

Hitomi Fujishiro, Satomi Okugaki, Sachi Nagao, Masahiko Satoh, and Seiichiro Himeno

Journal of Health Science, 52(3) 292-299(2006)
2006

Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection.

V.Khajoee, M.Saito, H.Takada, A.Nomura, K Kusuhara, S.-I.Yoshida, Y.Yoshikai and T. Hara

Clinical & Experimental Immunology, Vol143, Issue 2, pp260, 2006
2006

Multiple primer extension by DNA polymerase on a novel plastic DNA array coated with a biocompatible polymer.

Kinoshita K, Fujimoto K, Yakabe T, Saito S, Hamaguchi Y, Kikuchi T, Nonaka K, Murata S, Masuda D, Takada W, Funaoka S, Arai S, Nakanishi H, Yokoyama K, Fujiwara K, Matsubara K.

Nucleic Acids Research, doi:10.1093/nar/gkl939, 2006.
2006

Microarray analysis of promoter methylation in lung cancers

Masayuki Fukusawa・Mika Kimura・Sumiyo Mroita・Kenichi Matsubara・Sumitaka Yamanaka・Chiaki Endo・Akira Sakurada・Masami Sato・Takashi Kondo・Akira Horii・Hiroyuki Sasaki・Izuho hatada

J Hum Genet,51(4),(2006),368-374
2006

High throughput purification of amino-modified oligonucleotides and its application to novel detection system of gene expression.

Kojima N, Sugino M, Mikami A, Nonaka K, Fujinawa Y, Ueda Y, Sato K, Ohtsuka E, Matsubara K, Komatsu Y.

Nucleic Acids Sym. Ser., 49, 181-182 (2005).
2005

https://academic.oup.com/nass/article-abstract/49/1/181/1070343/High-throughput-purification-of-amino-modified?redirectedFrom=fulltext

Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome.

Tanaka T, Takada H, Nomura A, Ohga S, Shibata R, Hara T.

Clin Exp Immunol., 140(3), pp524-531, 2005
2005

Methylation-Associated Silencing of the Nuclear Receptor 1I2 Gene in Advanced-Type Neuroblastomas, Identified by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

Akiko Misawa, Jun Inoue, Yuriko Sugino, Hajime Hosei, Tohru Sugimoto, Fumie Hosoda, Misao Ohki, Issei Imoto and Johji Inazawa

Cancer Reserch, Vol.65, 10233-10242, 2005
2005

Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia

Mohd. Akhlakur Rahman, Yoshinao Azuma, Hajime Fukunaga, Tomoyuki Murakami, Kazurou Sugi, Hideto Fukushi, Koshiro Miura, Harumi Suzuki and Mutsunori Shirai

Journal of Antimicrobial Chemotherapy, 2005, 56(5):861-868
2005

Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma

Yuji Toyama, Akira Mizoguchi, Kazushi Kimura, Toshimitsu Araki, Shigeyuki Yoshiyama, Kouhei Sakaguchi, Chikao Miki, Masato Kusunoki

World J Gastroenterol 2005;11(33):5151-5155
2005

Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarray.

Megumi Takemoto, Ryutaro Kira, Koichi Kusuhara, Hiroyuki Torisu, Yasunari Sakai, Toshiro Hara

Journal of NeuroVirology, Vol11, No.3, 2005, pp299-305
2005

Recapitulation of in vivo gene expression during hepatic differentiation from murine embryonic stem cells

Yusuke Yamamoto, Takumi Teratani, Hanako Yamamoto ,Gary Quinn, Sigenori Murata, Rieko Ikeda, Kenji Kinoshita, Kenichi Matsubara, Takashi Kato, Takahiro Ochiya

Hepatology, Volume 42, Issue 3 (September 2005), (p 558-567)
2005

Psychophysiological stress-regulated gene expression in mice

Shigenori Murata, Taeko Yoshiara, Chun Ren Lim, Maiko Sugino, Mitori Kogure, Tatsuya Ohnuki, Toshi Komurasaki, Kenichi Matsubara

FEBS Letters, 579: 2137-2142, 2005
2005

Genetic basis of phenotypic plasticity for predator-induced morphological defenses in anuran tadpole, Rana pirica, using cDNA subtraction and microarray analysis

Tsukasa Mori, Ikuei Hiraka, Youichi Kurata, Hiroko Kawachi, Osamu Kishida, Kinya Nishimura

Biochemical and Biophysical Research Communications 330 (2005) 1138-1145
2005

Recapitulation of In Vivo Gene Expressuib During Hepatic Differrentiation From Murine Embryonic Stem Cells

Yusuke Ymamoto, Takumi Teratani, Hanko Yamamoto, Gary Quinn, Sigenori Murata, Rieko Ikeda, Kenji Kinoshita, Kenichi Matsubara, Takashi Kato, and Takahiro Ochiya

HEPATOLOGY vol. 42, No.3, 2005
2005

Synthesis and application of new amino modification analogues for functional oligonucleotide.

Komatsu Y, Kojima N, Nonaka K, Fujinawa Y, Sugino M, Mikami A, Hashida J, Ohtsuka E, Matsubara K.

Nucleic Acids Sym. Ser., 48, 21-22 (2004).
2004

https://academic.oup.com/nass/article-lookup/doi/10.1093/nass/48.1.21

Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes

Kumio OKAICHI, Miwa IDE, Aya Usui, and Yutaro OKUMURA

J. Radiat. Res., 45, 399-403 (2004)
2004

MRP-1/CD9 gene transduction downregulates Wnt signal pathways

Cheng-long Huang, Dage Liu, Daiki Masuya, Kotaro Kameyama, Takashi Nakashima, Hiroyasu Yokomise, Masaki Ueno and, Masayuki Miyake

Oncogene, Volume 23, Number 45, pp7475-7483, 2004
2004

Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma

Jun Inoue, Takemi Otsuki, Akira Hirasawa, Issei Imoto, Yoshinobu Matsuo, Shiroh Shimizu, Masafumi Taniwaki, and Johji Inazawa

American Journal of Pathology, Vol.165, No.1, 2004, pp71-81
2004

Prepro-tachykinin gene expression in the brain of the honeybee Apis mellifera

Hideaki Takeuchi, Akikazu Yasuda, Yoshimi Yasuda-Kamatani, Miyuki Sawata, Yuko Matsuo, Azusa Kato, Atsumi Tsujimoto, Terumi Nakajima, Takeo Kubo

Cell Tissue Res (2004) 316:281-293
2004

Identification of Differentially Expressed Genes Involved in Colorectal Carcinogenesis Using a cDNA Microarray

T. Komori, I. Takemasa, H. Higuchi, M. Yamasaki, M. Ikeda, H. Yamamoto, M. Ohue, S. Nakamori, M. Sekimoto, K. Matsubara and M. Monden

J Exp Clin Cancer Res. 2004 Sep;23(3):521-7
2004

Gene expression profiling of mouse postnatal cerebellar development using cDNA microarrays

Lim, C.R., Fukakusa, A. and Matsubara, K.

Gene. 2004 May 26;333:3-13
2004

Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth.

Ohdate, H., Lim, C.R., Kokubo, T., Matsubara, K., Kimata, Y. and Kohno, K.

J Biol Chem 278 (2003) 14647-56.
2003

cDNA microarray analysis of individual Duchenne muscular dystrophy patients

Noguchi S, Tsukahara T, Fujita M, Kurokawa R, Tachikawa M, Toda T, Tsujimoto A, Arahata K, Nishino I

Hum. Mol. Genetics, 12:595-600, 2003
2003

A Bayesian missing value estimation method for gene expression profile data

Shigeyuki Oba, Masa-aki Sato, Ichiro Takemasa, Morita Monden, Ken-chi Matsubara and Shin Ishii

Oxford Universiry Press Bioinformatics vol.19 nNo.16, 2003
2003

A novel feature of microsatellites in plants : a distribution gradient along the direction of transcription

Shigeo Fujimori, Takanori Washio, Kenichi Higo, Yasuhiro Ohtomo, Kazuo Murakami, Kenichi Matsubara, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Shoshi Kikuchi, Masaru Tomita

FEBS Letter 554, 2003
2003

DNA alterations during multi-step development of human hepatocellular carcinomas revealed by laser capture microdissection

Hisaki Nagai, Mitsuru Emi, Yoshie Terada, Masaru Baba, Masashi Shimizu, Noboru Konishi, Shuichi Kaneko, Kenichi Kobayashi, Yasuhiro umoto, Mohammed Ghazizadeh, Oichi Kawanami, Kenichi Matsubara

Hepatology Research Hepatology Research 26, 2003
2003

Collection, Mapping, and Annotation of Over 28,000 cDNA Clones from japonica Rice

National Institute of Agrobiological Sciences Rice Full-Length cDNA Project Team: Shoshi Kikuchi, Kouji Satoh, Toshifumi Nagata, Nobuyuki Kawagashira, Koji Doi, Naoki Kishimoto, Junshi Yazaki, Masahiro Ishikawa, Hitomi Yamada, Hisako Ooka, Isamu Hotta, Keiichi Kojima, Takahiro Nmki, Eisuke Ohneda, Wataru Yahagi, Kohji Suzuki, Chao Jie Li, Kenji Ohtsuki, Toru Shishiki; Foundation of Advancement of International Science Genome Sequencing & Analysis Group: Yasuhiro Otomo, kazuo Murakami, Yoshiharu Iida, SumioSugano, Tatsuto Fujinura, Yutaka Suzuki, Yuki Tsunoda, Takashi Kurosaki, Takeko Kodama, Hiromi Masuda, Michie Kobayashi, Quihong Xie, Min Lu, Ryuya Narikawa, Akio Sugiyama, Kouichi Mizuno, Satoko Yokomizo, JunkoNiikura, Rieko Ikeda, Junya Ishibbiki, Midori Kawamata, Akemi Yoshimura, Junichirou Miura, takahiro Kusumegi, Mitsuru oka, Riasaa Ryu, Mariko Ueda, Kenichi Matsubara; RIKEN: Jun Kawai, Piero Carninci, Jun Adachi, Katsunori Aizawa, Takahiro Arakawam Shiro Fukuda, Ayako Hara, Wataru Hasgudume, Norihito Hayatsu, Koichi Imotani, Yoshiki Ishii, Masayoshi Itoh, Ikuko Kagawa, Shinji Kondo, Kedeaki Konno, Ai Miyazakim Naoki Osatot, Yoshimi Ota, Rintaro Saito, Daisuke Sasaki, Kenjiro Sato, Kazuhiro Shibata, AkiraShinagawa, Toshiyuki Shiraki, Masayasu Yoshino, Yoshihide Hayashizaki

Science, vol. 301, No.5631, 2003
2003

Identification of genes expressed preferentially in the honeybee mushroom bodies by combination of differential display and cDNA microarray.

Takeuchi H, Fujiyuki T, Shirai K, Matsuo Y, Kamikouchi A, Fujinawa Y, Kato A, Tsujimoto A, Kubo T.

FEBS Letters, 513:230-234, 2002
2002

A microarray-based method for detecting methylated loci.

Hatada I, Kato A, Morita S, Obata Y, Horii A, Sato M, Sakurada A, Nagaoka K, Tsujimoto A, Matsubara K., J. Hum.

Genetics, 47:448-451, 2002
2002

In vitro selection of hairpin ribozymes activated with short oligonucleotides.

Komatsu, Y., Nobuoka, K., Karino-Abe, N., Matsuda, A. and Ohtsuka, E.

Biochemistry, 41, 9090-9098 (2002).
2002

Expression profile of active genes in the human pituitary gland

S Tanaka, K Tatsumi, K Okubo, K Itoh, S Kawamoto, K Matsubara and N Amino

Journal of Molecular Endocrinology No. 28, 2002
2002

Modulation of polyglutamine-induces cell death by genes idenitified by expression profiiling

Hiroko Kita, Jenny Carmicheal, Jina Swartz, Shizuko Muro, Andreas Wyttenbach, Kenichi Matsubara, David C. Rubinsztein and Kikuya Kato

Oxford Universiry Press Human Molecular Genetics, 2002, vol,11, no. 19
2002

Molecular classification of primary breast tumors possessing distinct prognostic properties

Kyoko Iwao, Ryo Matoba, Noriko Ueno, Akiko Ando, Yasuo Miyoshi, Kenichi Matsubra, Shinzaburo Noguchi and Kikuya Kato

Oxford Universiry Press Human Molecular Genetics, 2002, vol,11, no. 2
2002

Missing Value Estimation Using Mixture of PCAs

Shigeyuki Oba, Masa-aki Sato, Ichiro Takemasa, Morita Monden, Kenichi Matsubara and Shin Ishii

Artificial Neural Networks ICANN 2002
2002

Construction of new ribozymes requiring short regulator oligonucleotides as a cofactor.

Komatsu, Y., Yamashita, S., Kazama, N., Nobuoka, K. and Ohtsuka, E.

J. Mol. Biol. 299, 1231-1243 (2000).
2000

Regulation of ribozyme cleavage activity by oligonucleotides. “Catalytic Nucleic Acid Protocols”

Komatsu, Y. and Ohtsuka, E.

Methods in Molecular Biology 252, 165-177.