EGFR-NGSチェック

論文・学会発表(医療関係者様向け情報)

論文・学会発表

学会発表

第57回日本肺癌学会学術集会 ランチョンセミナー25 (LS25)
演題名: EGFR変異陽性肺癌における血中腫瘍DNAの動態病理
演者: 加藤 菊也(株式会社DNAチップ研究所/前大阪府立成人病センター研究所長)
発表日時: 2016年12月21日(水) 11:55 ~ 12:45
発表会場: 第8会場(福岡国際会議場 4F 413+414) / 福岡国際会議場4F 4A+4B

原著論文

Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data.
PLoS One. 2013 Nov 21;8(11):e81468.

Kukita Y1, Uchida J2, Oba S3,4, Nishino K2, Kumagai T2, Taniguchi K1, Okuyama T2, Imamura F2, Kato K1

  1. Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases
  2. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  3. Graduate School of Informatics, Kyoto University
  4. PRESTO, JST

Diagnostic Accuracy of Noninvasive Genotyping of EGFR in Lung Cancer Patients by Deep Sequencing of Plasma Cell-Free DNA.
Clin Chem. 2015 Sep;61(9):1191-6.

Uchida J1, Kato K2, Kukita Y3, Kumagai T1, Nishino K1, Daga H4, Nagatomo I5, Inoue T1, Kimura M1, Oba S6, Ito Y7, Takeda K4, Imamura F1.

  1. Department of Thoracic Oncology
  2. Department of Molecular and Medical Genetics, Research Institute
  3. Department of Molecular and Medical Genetics, Research Institute
  4. Department of Clinical Oncology, Osaka City General Hospital, Osaka, Japan
  5. Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
  6. Graduate School of Informatics, Kyoto University, Japan Science and Technology, Kyoto, Japan
  7. Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

Dynamics of circulating tumor DNA represented by the activating and resistant mutations in epidermal growth factor receptor tyrosine kinase inhibitor treatment.
Cancer Sci. 2016 Mar;107(3):353-8. doi: 10.1111/cas.12860. Epub 2016 Feb 18.

Uchida J1, Imamura F1, Kukita Y2, Oba S3, Kumagai T1, Nishino K1, Inoue T1, Kimura M1, Kato K2.

  1. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  2. Department of Molecular and Medical Genetics of Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  3. Graduate School of Informatics, Kyoto University, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kyoto, Japan.

Monitoring of treatment responses and clonal evolution of tumor cells by circulating tumor DNA of heterogeneous mutant EGFR genes in lung cancer
Lung Cancer. 2016 Apr;94:68-73. doi: 10.1016/j.lungcan.2016.01.023. Epub 2016 Feb 2.

Imamura F1, Uchida J2, Kukita Y3, Kumagai T2, Nishino K2, Inoue T2, Kimura M2, Oba S4, Kato K3.

  1. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  2. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  3. Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  4. Graduate School of Informatics, Kyoto University, Kyoto, Japan.

Numerical indices based on circulating tumor DNA for the evaluation of therapeutic response and disease progression in lung cancer patients.
Sci Rep. 2016 Jul 6;6:29093. doi: 10.1038/srep29093.

Kato K1, Uchida J2, Kukita Y1, Kumagai T2, Nishino K2, Inoue T2, Kimura M2, Oba S3, Imamura F2.

  1. Department of Molecular and Medical Genetics, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  2. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  3. Graduate School of Informatics, Kyoto University, Kyoto, Japan.

Early responses of EGFR circulating tumor DNA to EGFR tyrosine kinase inhibitors in lung cancer treatment.
Oncotarget. 2016 Sep 30. doi: 10.18632/oncotarget.12373.

Imamura F1, Uchida J1, Kukita Y2, Kumagai T1, Nishino K1, Inoue T1, Kimura M1, Kato K2.

  1. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  2. Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

New!
Transient appearance of circulating tumor DNA associated with de novo treatment.
Sci Rep. 2016 Dec 9;6:38639. doi: 10.1038/srep38639.

Kato K1, Uchida J2, Kukita Y1, Kumagai T2, Nishino K2, Inoue T2, Kimura M2, Imamura F2.

  1. Department of Molecular and Medical Genetics, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
  2. Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

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